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5c–d). CX-5461-mediated S33 phosphorylation of RPA was independent in the mobile cycle phase and was not limited into the nucleoli in HR-deficient cells. Thus, the formation of ssDNA buildings in CX-5461 treated cells may result in replication fork stalling and ATR activation with HRD exacerbating CX-5461-mediated replication pressure which cou
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Mastering and memory have been assessed using the Morris drinking water maze (MWM). Mice had been skilled to master a hidden System area from the MWM for four consecutive times (six trials/working day); Studying was defined to be a reducing latency to locate the System over the coaching period, whilst memory impairment was defined by reduced System